Colostrum Protein – Health Benefits of Colostrum

The nutritional profile of colostrum contains more than 1 million cells per milliliter, including macrophages, lymphocytes, neutrophils, epithelial cells, and complement, lactoferrin, and insulin-like growth factor. Colostrum also contains several proteins, including immunoglobulins and nonimmunoglobulins, which probably act both locally in the gut and systemically as modulators of the neonatal immune system.
Contains non-immunoglobulin proteins

Colostrum protein is a rich source of immunoglobulins and other beneficial components. It contains over one million cells per milliliter. It also contains immune cells and cytokines produced by the mother. The non-immunoglobulin portion likely acts locally within the gut, while the immunoglobulin portion is probably more systemic, modulating the neonatal immune system.


The growth factors in bovine colostrum are known to increase Ig levels and stimulate lymphocyte proliferation and phagocytosis. These proteins also contain lactoferrin and transferrin, which affect the membrane of a pathogen, making it more susceptible to attack by neutrophils. Moreover, colostrum is a rich source of cytokines and transfer factors, which increase the production of endogenous antibodies and regulate epithelial cell growth. Other growth factors present in colostrum include IGF-1 and IGF-2, FGF, EGF, and TGF.


Colostrum is a natural food rich in amino acids and bioactive factors. This protein-rich fluid provides passive immunity to the calf, which can help protect it from disease. It contains specific peptides and proteins that are important for the calf’s immune system. Further, it contains a variety of beneficial nutrients for the body. This article will explore some of the health benefits of colostrum.

Apo A-IV

ApoA-IV is a crucial component of the cholesterin-lipoprotein transport system. It has multiple roles in the regulation of glucose and lipid metabolism in rats. In addition, ApoA-IV can modulate hepatic TG secretion. Its presence may be essential for improving glucose homeostasis. Its role is also well-known in the development of diabetes.


Analyzing the bovine IgG content in milk and colostrum is important for a number of applications, including nutrition database information, quality control, and regulatory compliance. The analytical principles used to measure IgG in a milk-based matrix are diverse. Table 2 summarizes published studies to date. These methods can identify and quantify IgG in complex matrices. Typically, caseins are removed from the sample prior to analytical separation. Nonetheless, some studies report the simultaneous measurement of IgG and caseins.


Both whey and colostrum contain a compound known as lactoferrin. Lactoferrin is an iron-binding glycoprotein with properties that enhance iron absorption, enhance immune function, and stimulate fibroblasts and intestinal epithelial cells. Colostrum contains a-lactalbumin (a-LA) and b-lactoglobulin, two forms of amino acids that are essential for human growth and development.
Amino acids

Amino acids in Colostrum Protein are higher than those found in milk. They peak between 24 and 48 hours after parturition and then gradually decrease throughout lactation to reach their lowest level by the third week. Nucleosides, di-phosphates, and UDP galactose are the most abundant in colostrum. Milk has a much higher concentration of these amino acids.